The practicals really complement the lectures, whereas in the other courses I sometimes get the impression they are just giving us a practical as a formality. The practicals have actually helped me understand and appreciate a lot of the theoretical aspects of the course and in the debriefs the demonstrators often go over the essentials from a lecture series.
In addition BMB includes journal clubs, which help you understand how to actually read journals. It sounds trivial but before I went I could just about tolerate the abstract and conclusion. The main topics it builds on from first year cells are structure of molecules, metabolism, cell signalling and cancer/cell cycle.
The main drawback is that there is a lot of detail, so I would (personally) only advise picking this option if you are a selective learner.